An S101P Substitution in the Putative Cleavage Motif of the Human Metapneumovirus Fusion Protein Is a Major Determinant for Trypsin-Independent Growth in Vero Cells and Does Not Alter Tissue Tropism in Hamsters

Human metapneumovirus (hMPV), a recently described paramyxovirus, is a major etiological agent for lower respiratory tract disease in young children that can manifest with severe cough, bronchiolitis, and pneumonia. The hMPV fusion glycoprotein (F) shares conserved functional domains with other para...

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Detalhes bibliográficos
Main Authors: Schickli, Jeanne H., Kaur, Jasmine, Ulbrandt, Nancy, Spaete, Richard R., Tang, Roderick S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182652/
https://ncbi.nlm.nih.gov/pubmed/16051860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.16.10678-10689.2005
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