Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294

Avian metapneumovirus (aMPV) and human metapneumovirus (hMPV) are members of the genus Metapneumovirus in the subfamily Pneumovirinae. Metapneumovirus fusion (F) protein mediates the fusion of host cells with the virus membrane for infection. Trypsin- and/or low pH-induced membrane fusion is a strai...

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Publicado no:Sci Rep
Main Authors: Yun, Bingling, Guan, Xiaolu, Liu, Yongzhen, Gao, Yanni, Wang, Yongqiang, Qi, Xiaole, Cui, Hongyu, Liu, Changjun, Zhang, Yanping, Gao, Li, Li, Kai, Gao, Honglei, Gao, Yulong, Wang, Xiaomei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620442/
https://ncbi.nlm.nih.gov/pubmed/26498473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15584
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