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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

The PTEN and TSC2 tumor suppressors inhibit mammalian target of rapamycin (mTOR) signaling and are defective in distinct hamartoma syndromes. Using mouse genetics, we find that Pten and Tsc2 act synergistically to suppress the severity of a subset of tumors specific to loss of each of these genes. I...

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Autors principals: Manning, Brendan D., Logsdon, M. Nicole, Lipovsky, Alex I., Abbott, Derek, Kwiatkowski, David J., Cantley, Lewis C.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182339/
https://ncbi.nlm.nih.gov/pubmed/16027169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1314605
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