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Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development

During nerve development, Schwann cells (SCs) build multilayered myelin sheaths around axons to accelerate nerve conduction. The mechanistic target of rapamycin complex 1 (mTORC1) downstream of PI3K/AKT signaling lately emerged as a central anabolic regulator of myelination. Using mutant mice with s...

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Publicat a:Commun Integr Biol
Autors principals: Wong, Keit Men, Beirowski, Bogdan
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824964/
https://ncbi.nlm.nih.gov/pubmed/29497474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420889.2018.1433441
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