Loading...
A complex interplay between Akt, TSC2, and the two mTOR complexes
Akt/PKB both regulates and is regulated by the TSC1-TSC2 complex. Downstream of phosphoinositide 3-kinase (PI3K), Akt directly phosphorylates TSC2 on multiple sites. While the molecular mechanism is not well understood, these phosphorylation events relieve the inhibitory effects of the TSC1-TSC2 com...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2778026/ https://ncbi.nlm.nih.gov/pubmed/19143635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST0370217 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|