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The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gene products form a complex that has become the focus of many signal transduction researchers. The TSC1–TSC2 (hamartin–tuberin) complex, through its GAP (GTPase-activating protein) a...

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Detalhes bibliográficos
Main Authors: HUANG, Jingxiang, MANNING, Brendan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735030/
https://ncbi.nlm.nih.gov/pubmed/18466115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080281
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