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S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
Feedback inhibition of the PI3K-Akt pathway by the mammalian target of rapamycin complex 1 (mTORC1) has emerged as an important signaling event in tumor syndromes, cancer, and insulin resistance. Cells lacking the tuberous sclerosis complex (TSC) gene products are a model for this feedback regulatio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1880887/ https://ncbi.nlm.nih.gov/pubmed/17052453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.09.019 |
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