Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway

Cytokine signaling by the Jak–STAT pathway is subject to complex negative regulation that limits the amplitude and duration of signal transduction. Inhibition of signaling also mediates negative crosstalk, whereby factors with opposing biological activities crossinhibit each other's function. H...

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Bibliographische Detailangaben
Hauptverfasser: Du, Zhimei, Shen, Yuhong, Yang, Wentian, Mecklenbrauker, Ingrid, Neel, Benjamin G., Ivashkiv, Lionel B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177356/
https://ncbi.nlm.nih.gov/pubmed/16000408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408854102
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