Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity

Calcium influx can promote neuronal differentiation and survival, at least in part by activating Ras and its downstream targets, including the Erk pathway. However, excessive calcium influx can initiate molecular signals leading to neuronal death during excitotoxicity or in neurodegenerative disease...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Rusanescu, Gabriel, Yang, Wentian, Bai, Ailin, Neel, Benjamin G, Feig, Larry A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2005
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15650750/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600522
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