Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity

Calcium influx can promote neuronal differentiation and survival, at least in part by activating Ras and its downstream targets, including the Erk pathway. However, excessive calcium influx can initiate molecular signals leading to neuronal death during excitotoxicity or in neurodegenerative disease...

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Bibliographic Details
Published in:EMBO J
Main Authors: Rusanescu, Gabriel, Yang, Wentian, Bai, Ailin, Neel, Benjamin G, Feig, Larry A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2005
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Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545812/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15650750/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600522
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