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Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity
Calcium influx can promote neuronal differentiation and survival, at least in part by activating Ras and its downstream targets, including the Erk pathway. However, excessive calcium influx can initiate molecular signals leading to neuronal death during excitotoxicity or in neurodegenerative disease...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2005
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545812/ https://ncbi.nlm.nih.gov/pubmed/15650750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600522 |
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