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Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity
Calcium influx can promote neuronal differentiation and survival, at least in part by activating Ras and its downstream targets, including the Erk pathway. However, excessive calcium influx can initiate molecular signals leading to neuronal death during excitotoxicity or in neurodegenerative disease...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545812/ https://ncbi.nlm.nih.gov/pubmed/15650750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600522 |
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