Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway

Cytokine signaling by the Jak–STAT pathway is subject to complex negative regulation that limits the amplitude and duration of signal transduction. Inhibition of signaling also mediates negative crosstalk, whereby factors with opposing biological activities crossinhibit each other's function. H...

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Detalles Bibliográficos
Main Authors: Du, Zhimei, Shen, Yuhong, Yang, Wentian, Mecklenbrauker, Ingrid, Neel, Benjamin G., Ivashkiv, Lionel B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177356/
https://ncbi.nlm.nih.gov/pubmed/16000408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408854102
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