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Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase

On the basis of ex vivo studies using insulin-responsive cells, activation of a Class IA phosphoinositide 3-kinase (PI3K) seems to be required for a wide variety of cellular responses downstream of insulin. The Class IA PI3K enzymes are heterodimers of catalytic and regulatory subunits. In mammals,...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Ueki, Kohjiro, Yballe, Claudine M., Brachmann, Saskia M., Vicent, David, Watt, John M., Kahn, C. Ronald, Cantley, Lewis C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117575/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752399/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012581799
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