The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

The molecular characterization of leukemia has demonstrated that genetic alterations in the leukemic clone frequently fall into 2 classes, those affecting transcription factors (e.g., AML1-ETO) and mutations affecting genes involved in signal transduction (e.g., activating mutations of FLT3 and KIT)...

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Autores principales: Schessl, Christina, Rawat, Vijay P.S., Cusan, Monica, Deshpande, Aniruddha, Kohl, Tobias M., Rosten, Patricia M., Spiekermann, Karsten, Humphries, R. Keith, Schnittger, Susanne, Kern, Wolfgang, Hiddemann, Wolfgang, Quintanilla-Martinez, Leticia, Bohlander, Stefan K., Feuring-Buske, Michaela, Buske, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174917/
https://ncbi.nlm.nih.gov/pubmed/16025155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24225
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