Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia

Creation of fusion genes by balanced chromosomal translocations is one of the hallmarks of acute myeloid leukemia (AML) and is considered one of the key leukemogenic events in this disease. In t(12;13)(p13;q12) AML, ectopic expression of the homeobox gene CDX2 was detected in addition to expression...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Rawat, Vijay P. S., Cusan, Monica, Deshpande, Aniruddha, Hiddemann, Wolfgang, Quintanilla-Martinez, Leticia, Humphries, R. Keith, Bohlander, Stefan K., Feuring-Buske, Michaela, Buske, Christian
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321764/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14718672/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0305555101
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