A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis

Canonical Wnt signaling is critically involved in normal hematopoietic development and the self-renewal process of hematopoietic stem cells (HSCs). Deregulation of this pathway has been linked to a large variety of cancers, including different subtypes of leukemia. Lef-1 is a major transcription fac...

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Hlavní autoři: Petropoulos, Konstantin, Arseni, Natalia, Schessl, Christina, Stadler, Christiane R., Rawat, Vijay P.S., Deshpande, Aniruddha J., Heilmeier, Bernhard, Hiddemann, Wolfgang, Quintanilla-Martinez, Leticia, Bohlander, Stefan K., Feuring-Buske, Michaela, Buske, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2008
Témata:
Brief Definitive Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275375/
https://ncbi.nlm.nih.gov/pubmed/18316418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071875
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