Differential role of SLP-76 domains in T cell development and function

The adapter SLP-76 is essential for thymocyte development. SLP-76(−/−) mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mi...

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Bibliographic Details
Main Authors: Kumar, Lalit, Pivniouk, Vadim, de la Fuente, Miguel A., Laouini, Dhafer, Geha, Raif S.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC117400/
https://ncbi.nlm.nih.gov/pubmed/11792851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022619199
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