Structural Requirements of SLP-76 in Signaling via the High-Affinity Immunoglobulin E Receptor (FcɛRI) in Mast Cells

The adapter SLP-76 plays an essential role in FcɛRI signaling, since SLP-76(−/−) bone marrow-derived mast cells (BMMC) fail to degranulate and release interleukin-6 (IL-6) following FcɛRI ligation. To define the role of SLP-76 domains and motifs in FcɛRI signaling, SLP-76(−/−) BMMC were retrovirally...

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Detalhes bibliográficos
Main Authors: Kettner, Alexander, Pivniouk, Vadim, Kumar, Lalit, Falet, Hervé, Lee, Jeng-Shin, Mulligan, Richard, Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150723/
https://ncbi.nlm.nih.gov/pubmed/12640123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2395-2406.2003
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