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Multiple hematopoietic defects and delayed globin switching in Ikaros null mice

We have previously reported the structure of a chromatin remodeling complex (PYR complex) with Ikaros as its DNA binding subunit that is specifically present in adult murine and human hematopoietic cells. We now show that homozygous Ikaros “knockout” (null) mice lack the PYR complex, demonstrating t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lopez, Rocio A., Schoetz, Stuti, DeAngelis, Kathryn, O'Neill, David, Bank, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117352/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11805317/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022412699
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