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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.
The p53 tumour suppressor protein is a labile transcription factor that is activated and stabilized in response to a wide range of cellular stresses, through a mechanism involving disruption of its interaction with MDM2, a negative regulatory partner. Induction of p53 by DNA damage additionally invo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171763/ https://ncbi.nlm.nih.gov/pubmed/10601022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.24.7002 |
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