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Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover.

The p53 tumour suppressor protein is a short-lived transcription factor that becomes stabilized in response to a wide range of cellular stresses. Ubiquitination and the targeting of p53 for degradation by the proteasome are mediated by Mdm2 (mouse double minute clone 2), a negative regulatory partne...

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Main Authors: Dumaz, N, Milne, D M, Jardine, L J, Meek, D W
格式: Artigo
語言:Inglês
出版: 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222167/
https://ncbi.nlm.nih.gov/pubmed/11583595
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