Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

The p53 tumour suppressor is induced by various stress stimuli and coordinates an adaptive gene expression programme leading to growth arrest or cell death. Some stimuli, such as DNA damage, lead to rapid and substantial multisite phosphorylation of p53, nucleated initially through phosphorylation o...

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Bibliographic Details
Main Authors: Loughery, Jayne, Cox, Miranda, Smith, Linda M., Meek, David W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081099/
https://ncbi.nlm.nih.gov/pubmed/24928858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku501
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