Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress

CABIN1 acts as a negative regulator of p53 by keeping p53 in an inactive state on chromatin. Genotoxic stress causes rapid dissociation of CABIN1 and activation of p53. However, its molecular mechanism is still unknown. Here, we reveal the phosphorylation- and ubiquitination-dependent degradation of...

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Bibliografske podrobnosti
Main Authors: Choi, Soo-Youn, Jang, Hyonchol, Roe, Jae-Seok, Kim, Seong-Tae, Cho, Eun-Jung, Youn, Hong-Duk
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575827/
https://ncbi.nlm.nih.gov/pubmed/23303793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1319
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