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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

The p53 tumour suppressor protein is a labile transcription factor that is activated and stabilized in response to a wide range of cellular stresses, through a mechanism involving disruption of its interaction with MDM2, a negative regulatory partner. Induction of p53 by DNA damage additionally invo...

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書目詳細資料
Main Authors: Dumaz, N, Meek, D W
格式: Artigo
語言:Inglês
出版: 1999
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171763/
https://ncbi.nlm.nih.gov/pubmed/10601022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.24.7002
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