Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells.

Murine double minute clone 2 oncoprotein (MDM2) is a key component in the regulation of the tumour suppressor p53. MDM2 mediates the ubiqutination of p53 in the capacity of an E3 ligase and targets p53 for rapid degradation by the proteasome. Stress signals which impinge on p53, leading to its activ...

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Autores principales: Hjerrild, M, Milne, D, Dumaz, N, Hay, T, Issinger, O G, Meek, D
Formato: Artigo
Lenguaje:Inglês
Publicado: 2001
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221745/
https://ncbi.nlm.nih.gov/pubmed/11284721
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