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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis.

Expression of the pro-apoptotic molecule BAX has been shown to induce cell death. While BAX forms both homo- and heterodimers, questions remain concerning its native conformation in vivo and which moiety is functionally active. Here we demonstrate that a physiologic death stimulus, the withdrawal of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gross, A, Jockel, J, Wei, M C, Korsmeyer, S J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1998
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170723/
https://ncbi.nlm.nih.gov/pubmed/9670005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.14.3878
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