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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis.
Expression of the pro-apoptotic molecule BAX has been shown to induce cell death. While BAX forms both homo- and heterodimers, questions remain concerning its native conformation in vivo and which moiety is functionally active. Here we demonstrate that a physiologic death stimulus, the withdrawal of...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1998
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170723/ https://ncbi.nlm.nih.gov/pubmed/9670005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.14.3878 |
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