IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.

Inhibitor of apoptosis (IAP) gene products play an evolutionarily conserved role in regulating programmed cell death in diverse species ranging from insects to humans. Human XIAP, cIAP1 and cIAP2 are direct inhibitors of at least two members of the caspase family of cell death proteases: caspase-3 a...

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Détails bibliographiques
Auteurs principaux: Deveraux, Q L, Roy, N, Stennicke, H R, Van Arsdale, T, Zhou, Q, Srinivasula, S M, Alnemri, E S, Salvesen, G S, Reed, J C
Format: Artigo
Langue:Inglês
Publié: 1998
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170566/
https://ncbi.nlm.nih.gov/pubmed/9545235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.8.2215
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