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Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.
A phylogenetically conserved transcriptional enhancer necessary for the activation of Hoxd-11 was deleted from the HoxD complex of mice by targeted mutagenesis. While genetic and expression analyses demonstrated the role of this regulatory element in the activation of Hoxd-11 during early somitogene...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1997
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170065/ https://ncbi.nlm.nih.gov/pubmed/9250683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.14.4393 |
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