Chromatin topology and the timing of enhancer function at the HoxD locus

The HoxD gene cluster is critical for proper limb formation in tetrapods. In the emerging limb buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal, then to a distal signal that organizes digits. These two regulations are exclusive from one another and emanate from t...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Rodríguez-Carballo, Eddie, Lopez-Delisle, Lucille, Willemin, Andréa, Beccari, Leonardo, Gitto, Sandra, Mascrez, Bénédicte, Duboule, Denis
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733857/
https://ncbi.nlm.nih.gov/pubmed/33229569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015083117
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