Large scale genomic reorganization of topological domains at the HoxD locus

BACKGROUND: The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is controlled by r...

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Detalles Bibliográficos
Publicado en:Genome Biol
Main Authors: Fabre, Pierre J., Leleu, Marion, Mormann, Benjamin H., Lopez-Delisle, Lucille, Noordermeer, Daan, Beccari, Leonardo, Duboule, Denis
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547506/
https://ncbi.nlm.nih.gov/pubmed/28784160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1278-z
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