Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

Gelijkaardige items

• Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
  door: Jefferies, H B, et al.
  Gepubliceerd in: (1994)
• Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation
  door: Duncan, Roger F.
  Gepubliceerd in: (2008)
• S6K1(−/−)/S6K2(−/−) Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
  door: Pende, Mario, et al.
  Gepubliceerd in: (2004)
• Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation
  door: Tang, Hua, et al.
  Gepubliceerd in: (2001)
• The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.
  door: Dennis, P B, et al.
  Gepubliceerd in: (1996)