Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

Treatment of mammalian cells with the immunosuppressant rapamycin, a bacterial macrolide, selectively suppresses mitogen-induced translation of an essential class of mRNAs which contain an oligopyrimidine tract at their transcriptional start (5'TOP), most notably mRNAs encoding ribosomal protei...

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Autores principales: Jefferies, H B, Fumagalli, S, Dennis, P B, Reinhard, C, Pearson, R B, Thomas, G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169993/
https://ncbi.nlm.nih.gov/pubmed/9218810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.12.3693
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