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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.
Treatment of mammalian cells with the immunosuppressant rapamycin, a bacterial macrolide, selectively suppresses mitogen-induced translation of an essential class of mRNAs which contain an oligopyrimidine tract at their transcriptional start (5'TOP), most notably mRNAs encoding ribosomal protei...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169993/ https://ncbi.nlm.nih.gov/pubmed/9218810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.12.3693 |
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