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Calcineurin is required for virulence of Cryptococcus neoformans.

Cyclosporin A (CsA) and FK506 are antimicrobial, immunosuppressive natural products that inhibit signal transduction. In T cells and Saccharomyces cerevisiae, CsA and FK506 bind to the immunophilins cyclophilin A and FKBP12 and the resulting complexes inhibit the Ca2+-regulated protein phosphatase c...

詳細記述

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書誌詳細
主要な著者: Odom, A, Muir, S, Lim, E, Toffaletti, D L, Perfect, J, Heitman, J
フォーマット: Artigo
言語:Inglês
出版事項: 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169869/
https://ncbi.nlm.nih.gov/pubmed/9184205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2576
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