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Calcineurin is required for virulence of Cryptococcus neoformans.
Cyclosporin A (CsA) and FK506 are antimicrobial, immunosuppressive natural products that inhibit signal transduction. In T cells and Saccharomyces cerevisiae, CsA and FK506 bind to the immunophilins cyclophilin A and FKBP12 and the resulting complexes inhibit the Ca2+-regulated protein phosphatase c...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169869/ https://ncbi.nlm.nih.gov/pubmed/9184205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2576 |
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