Calcineurin is required for virulence of Cryptococcus neoformans.

Cyclosporin A (CsA) and FK506 are antimicrobial, immunosuppressive natural products that inhibit signal transduction. In T cells and Saccharomyces cerevisiae, CsA and FK506 bind to the immunophilins cyclophilin A and FKBP12 and the resulting complexes inhibit the Ca2+-regulated protein phosphatase c...

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Detalhes bibliográficos
Main Authors: Odom, A, Muir, S, Lim, E, Toffaletti, D L, Perfect, J, Heitman, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169869/
https://ncbi.nlm.nih.gov/pubmed/9184205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2576
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