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Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells.
Nonsense codons upstream of and including position 192 of the human gene for triosephosphate isomerase (TPI) have been found to reduce the abundance of TPI mRNA to approximately 25% of normal. The reduction is due to the decay of newly synthesized TPI mRNA that co-purifies with nuclei. TPI mRNA that...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169683/ https://ncbi.nlm.nih.gov/pubmed/9049311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.4.826 |
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