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Mutagenesis Analysis of a Conserved Region Involved in Acetyl Coenzyme A Binding in the Aminoglycoside 6′-N-Acetyltransferase Type Ib Encoded by Plasmid pJHCMW1
Alanine scanning of motif A in the pJHCMW1-encoded aminoglycoside 6′-N-acetyltransferase type Ib identified amino acids important for the ability of the enzyme to confer wild-type levels of resistance to kanamycin and amikacin. The replacement of two amino acids, D117 or L120, with alanine residues...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Microbiology
2005
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1168681/ https://ncbi.nlm.nih.gov/pubmed/15980378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2979-2982.2005 |
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