Mutagenesis Analysis of a Conserved Region Involved in Acetyl Coenzyme A Binding in the Aminoglycoside 6′-N-Acetyltransferase Type Ib Encoded by Plasmid pJHCMW1

Alanine scanning of motif A in the pJHCMW1-encoded aminoglycoside 6′-N-acetyltransferase type Ib identified amino acids important for the ability of the enzyme to confer wild-type levels of resistance to kanamycin and amikacin. The replacement of two amino acids, D117 or L120, with alanine residues...

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Détails bibliographiques
Auteurs principaux: Pourreza, Atousa, Witherspoon, Mavee, Fox, Jessica, Newmark, Jason, Bui, Duyen, Tolmasky, Marcelo E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168681/
https://ncbi.nlm.nih.gov/pubmed/15980378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2979-2982.2005
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