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1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: An anticancer agent targeting hypoxic cells

To target malignant cells residing in hypoxic regions of solid tumors, we have designed and synthesized prodrugs generating the cytotoxic alkylating species 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) after bioreductive activation. We postulate that one of these agents, 1,2-bis(methyls...

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Bibliografske podrobnosti
Main Authors: Seow, Helen A., Penketh, Philip G., Shyam, Krishnamurthy, Rockwell, Sara, Sartorelli, Alan C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166587/
https://ncbi.nlm.nih.gov/pubmed/15964988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409013102
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