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Phosphorylation of Simian Virus 40 T Antigen on Thr 124 Selectively Promotes Double-Hexamer Formation on Subfragments of the Viral Core Origin

Cell cycle-dependent phosphorylation of simian virus 40 (SV40) large tumor antigen (T-ag) on threonine 124 is essential for the initiation of viral DNA replication. A T-ag molecule containing a Thr→Ala substitution at this position (T124A) was previously shown to bind to the SV40 core origin but to...

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Udgivet i:J Virol
Principais autores: Barbaro, Brett A., Sreekumar, K. R., Winters, Danielle R., Prack, Andrea E., Bullock, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116373/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954562/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.18.8601-8613.2000
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