Two Regions of Simian Virus 40 T Antigen Determine Cooperativity of Double-Hexamer Assembly on the Viral Origin of DNA Replication and Promote Hexamer Interactions during Bidirectional Origin DNA Unwinding

Phosphorylation of simian virus 40 large tumor (T) antigen on threonine 124 is essential for viral DNA replication. A mutant T antigen (T124A), in which this threonine was replaced by alanine, has helicase activity, assembles double hexamers on viral-origin DNA, and locally distorts the origin DNA s...

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Hauptverfasser: Weisshart, Klaus, Taneja, Poonam, Jenne, Andreas, Herbig, Utz, Simmons, Daniel T., Fanning, Ellen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC104465/
https://ncbi.nlm.nih.gov/pubmed/9971803
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