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Study of SV40 large T antigen nucleotide specificity for DNA unwinding

Abstract Background Simian Virus 40 (SV40) Large Tumor Antigen (LT) is an essential enzyme that plays a vital role in viral DNA replication in mammalian cells. As a replicative helicase and initiator, LT assembles as a double-hexamer at the SV40 origin to initiate genomic replication. In this proces...

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Principais autores: Damian Wang, Ana Lucia Álvarez-Cabrera, Xiaojiang S. Chen
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2017-04-01
סדרה:Virology Journal
נושאים:
SV40 virus
SV40 large t antigen
Replicative helicase
DNA replication
Nucleotide binding and hydrolysis
Nucleotide specificity for unwinding
גישה מקוונת:http://link.springer.com/article/10.1186/s12985-017-0733-5
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