Two Regions of Simian Virus 40 T Antigen Determine Cooperativity of Double-Hexamer Assembly on the Viral Origin of DNA Replication and Promote Hexamer Interactions during Bidirectional Origin DNA Unwinding

Phosphorylation of simian virus 40 large tumor (T) antigen on threonine 124 is essential for viral DNA replication. A mutant T antigen (T124A), in which this threonine was replaced by alanine, has helicase activity, assembles double hexamers on viral-origin DNA, and locally distorts the origin DNA s...

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Detaylı Bibliyografya

Yayımlandı:	J Virol
Asıl Yazarlar:	Weisshart, Klaus, Taneja, Poonam, Jenne, Andreas, Herbig, Utz, Simmons, Daniel T., Fanning, Ellen
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 1999
Konular:	Replication
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104465/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9971803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.3.2201-2211.1999
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