Two Regions of Simian Virus 40 T Antigen Determine Cooperativity of Double-Hexamer Assembly on the Viral Origin of DNA Replication and Promote Hexamer Interactions during Bidirectional Origin DNA Unwinding

Phosphorylation of simian virus 40 large tumor (T) antigen on threonine 124 is essential for viral DNA replication. A mutant T antigen (T124A), in which this threonine was replaced by alanine, has helicase activity, assembles double hexamers on viral-origin DNA, and locally distorts the origin DNA s...

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Vydáno v:	J Virol
Hlavní autoři:	Weisshart, Klaus, Taneja, Poonam, Jenne, Andreas, Herbig, Utz, Simmons, Daniel T., Fanning, Ellen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1999
Témata:	Replication
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104465/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9971803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.3.2201-2211.1999
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