Paracrine Inhibition of Prion Propagation by Anti-PrP Single-Chain Fv Miniantibodies

Prion diseases are characterized by the deposition of PrP(Sc), an abnormal form of the cellular prion protein PrP(C). A growing body of evidence suggests that antibodies to PrP(C) can antagonize deposition of PrP(Sc). However, host tolerance hampers the induction of immune responses to PrP(C), and c...

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Detalhes bibliográficos
Main Authors: Donofrio, Gaetano, Heppner, Frank L., Polymenidou, Magdalini, Musahl, Christine, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143714/
https://ncbi.nlm.nih.gov/pubmed/15956578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.13.8330-8338.2005
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