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Axonal Damage Is T Cell Mediated and Occurs Concomitantly with Demyelination in Mice Infected with a Neurotropic Coronavirus

Mice infected with mouse hepatitis virus (MHV) strain JHM develop primary demyelination. Herein we show that axonal damage occurred in areas of demyelination and also in adjacent areas devoid of myelin damage. Immunodeficient MHV-infected RAG1−/− mice (mice defective in recombinase activating gene 1...

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Udgivet i:J Virol
Principais autores: Dandekar, Ajai A., Wu, Gregory F., Pewe, Lecia, Perlman, Stanley
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114327/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390613/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.13.6115-6120.2001
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