Antibody-Mediated Protection against Cytotoxic T-Cell Escape in Coronavirus-Induced Demyelination

C57BL/6 (B6) mice infected with mouse hepatitis virus (MHV) strain JHM develop a clinically evident, demyelinating encephalomyelitis. Infectious virus can be isolated from the spinal cords of these mice and is invariably mutated in the immunodominant CD8 T-cell epitope recognized in this strain. We...

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Detalhes bibliográficos
Main Authors: Dandekar, Ajai A., Jacobsen, Gary, Waldschmidt, Thomas J., Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC254260/
https://ncbi.nlm.nih.gov/pubmed/14581523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.22.11867-11874.2003
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