Axonal Damage Is T Cell Mediated and Occurs Concomitantly with Demyelination in Mice Infected with a Neurotropic Coronavirus

Mice infected with mouse hepatitis virus (MHV) strain JHM develop primary demyelination. Herein we show that axonal damage occurred in areas of demyelination and also in adjacent areas devoid of myelin damage. Immunodeficient MHV-infected RAG1−/− mice (mice defective in recombinase activating gene 1...

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Detalhes bibliográficos
Main Authors: Dandekar, Ajai A., Wu, Gregory F., Pewe, Lecia, Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114327/
https://ncbi.nlm.nih.gov/pubmed/11390613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.6115-6120.2001
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