Adaptation of Reovirus to Growth in the Presence of Protease Inhibitor E64 Segregates with a Mutation in the Carboxy Terminus of Viral Outer-Capsid Protein ς3

Reovirus virions are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis leading to degradation of ς3 protein and proteolytic cleavage of μ1/μ1C protein. E64 is a specific inhibitor of cysteine-contai...

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Bibliographic Details
Main Authors: Ebert, Daniel H., Wetzel, J. Denise, Brumbaugh, David E., Chance, Stacey R., Stobie, Laura E., Baer, Geoffrey S., Dermody, Terence S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114113/
https://ncbi.nlm.nih.gov/pubmed/11238846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3197-3206.2001
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