Reovirus Variants Selected for Resistance to Ammonium Chloride Have Mutations in Viral Outer-Capsid Protein σ3

Mammalian reoviruses are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis resulting in removal of the σ3 protein and proteolytic cleavage of the μ1/μ1C protein. Ammonium chloride (AC) is a weak bas...

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Autores principales: Clark, Kimberly M., Wetzel, J. Denise, Gu, Yingqi, Ebert, Daniel H., McAbee, Stephanie A., Stoneman, Emily K., Baer, Geoffrey S., Zhu, Yuwei, Wilson, Gregory J., Prasad, B. V. V., Dermody, Terence S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346852/
https://ncbi.nlm.nih.gov/pubmed/16378970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.671-681.2006
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