Reovirus Variants Selected for Resistance to Ammonium Chloride Have Mutations in Viral Outer-Capsid Protein σ3

Mammalian reoviruses are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis resulting in removal of the σ3 protein and proteolytic cleavage of the μ1/μ1C protein. Ammonium chloride (AC) is a weak bas...

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Detalhes bibliográficos
Main Authors: Clark, Kimberly M., Wetzel, J. Denise, Gu, Yingqi, Ebert, Daniel H., McAbee, Stephanie A., Stoneman, Emily K., Baer, Geoffrey S., Zhu, Yuwei, Wilson, Gregory J., Prasad, B. V. V., Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346852/
https://ncbi.nlm.nih.gov/pubmed/16378970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.2.671-681.2006
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